When a college career at the University of Southern Mississippi, Weatherspoon was selected by the Philadelphia 76ers as the Ninth pick of the 1992 NBA Draft. He has since played for a 76ers, the Golden State Warriors, the Miami Heat, the Cleveland Cavaliers, the New York Knicks and the Houston Rockets, averaging 11.Quintuplet points by the game throughout his career.

At six-foot-seven-inches & 250 pounds, he was nicknamed "Baby Barkley" early when you took his career due to the similar aggressive swimming style attributed to fellow short-statured NBA star power forward & previous 76er, Charles Barkley.